Low-Dose Acetazolamide in the Treatment of Premenstrual Dysphoric Disorder: A Case Series

نویسندگان

  • Gabriele Sani
  • Georgios D. Kotzalidis
  • Isabella Panaccione
  • Alessio Simonetti
  • Lavinia De Chiara
  • Antonio Del Casale
  • Elisa Ambrosi
  • Flavia Napoletano
  • Delfina Janiri
  • Emanuela Danese
  • Nicoletta Girardi
  • Chiara Rapinesi
  • Daniele Serata
  • Giovanni Manfredi
  • Alexia E. Koukopoulos
  • Gloria Angeletti
  • Ferdinando Nicoletti
  • Paolo Girardi
چکیده

The treatment of premenstrual dysphoric disorder (PMDD) is far from satisfactory, as there is a high proportion of patients who do not respond to conventional treatment. The antidiuretic sulfonamide, acetazolamide, inhibits carbonic anhydrase and potentiates GABAergic transmission; the latter is putatively involved in PMDD. We therefore tried acetazolamide in a series of women with intractable PMDD. Here, we describe a series of eight women diagnosed with DSM-IV-TR PMDD, five of whom had comorbidity with a mood disorder and one with an anxiety disorder, who were resistant to treatment and responded with symptom disappearance after being added-on 125 mg/day acetazolamide for 7-10 days prior to menses each month. Patients were free from premenstrual symptoms at the 12-month follow-up. We suggest that acetazolamide may be used to improve symptoms of PMDD in cases not responding to other treatments. GABAergic mechanisms may be involved in counteracting PMDD symptoms.

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عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2014